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Altogen Labs Xenograft Services for Drug Development Studies of Anticancer Therapeutics

Altogen Labs announced addition of five new in-house validated xenograft models (4T1, BxPC-3, Calu-6, MDA-MB-468, and PANC-1). This will make a total of 89 CDX xenograft models and 29 PDX xenograft models provided by Altogen Labs. Murine models have been used to investigate human cancer, enabling the discovery and development of new anticancer medicines. Xenograft studies are known as the gold standard for oncology research and the primary means for laboratory evaluation of anticancer compounds in preclinical research and drug discovery. Altogen Labs scientists developed over 100 xenograft models (89 CDX and 29 PDX murine immunocompromised models), as well as over 40 syngeneic models that have been used to investigate human cancer and to examine therapeutic responses to novel drugs in vivo. Company provides GLP-compliant contract research (CRO) services using any of in-house validated xenograft models. Altogen Labs scientists offer support and assistance in choosing the most suitable model for the customer’s experimental needs.

Xenograft studies, over in vitro studies, provide a more accurate and relevant results for both the development of a particular tumor as well as the efficacy of a novel anticancer drug. Profiling a therapeutic agent includes carrying out studies in different tumor types and evaluating efficacy with hematology analysis, histopathology, biomarker screening and pharmacokinetic analysis. These studies investigate gene expression changes, drug efficacy, host longevity, metastases decline, delay in tumor growth and remission of tumor. Altogen Labs scientists possess years of experience and can assist with customizing the services in order to assist with designing the study and selecting the best xenograft model.

Xenograft models are a powerful research tool to determine the ideal drug dosage, treatment schedules and specific routes of administration to optimize the anti-tumor efficacy of an anticancer agent. Altogen Labs performs a comprehensive analysis of tumorigenicity, cancer recurrence, and tumor drug resistance, as well as effectiveness of new drug candidates against different types of malignancies. Altogen Labs xenograft research studies are performed at Altogen Labs IACUC-regulated facility since 2009.

Altogen Labs (AltogenLabs.com) is a GLP-compliant contract research organization (biology CRO) located in Austin, Texas (USA) that provides all types of preclinical research services, including pharmacology and oncology contract research services for pharmaceutical companies, cancer research centers, and biotechnology companies worldwide.

Medical Discovery and Innovation: Altogen Labs Preclinical CRO Services

Altogen Labs (altogenlabs.com), an Austin, TX based contract research organization (CRO) offers preclinical laboratory services to pharmaceutical, biotechnology, and academic researchers worldwide to support and accelerate medical discovery and research studies. Our Good Laboratory Practice (GLP)-compliant laboratory offers services for drug toxicology, drug efficacy, drug discovery and new medicine development, specifically supporting preclinical investigation with in vitro and in vivo… Continue Reading

Altogen Labs offers xenograft services for drug development of anti-cancer therapeutics

Altogen Labs provides xenograft services for drug development studies of anti-cancer therapeutics by Altogen Labs, Preclinical CRO, 11200 Manchaca Rd, Suite 203 Austin TX 78744 USA (512-433-6177) Contact e-mail: info@altogenlabs.com Introduction Xenograft studies fuels the development of new therapeutics efficiently and effectively and remains the gold standard for preclinical oncology research [1]. Xenograft studies, over… Continue Reading

Preclinical Contract Research Studies by Global Health & Pharma

Altogen Labs is a good laboratory practice (GLP) compliant laboratory that provides biotechnology research services for pharmaceutical, biotechnology, and academic institutions worldwide. Altogen Labs services include safety in vivo toxicology studies (for IND applications), efficacy studies (for regulatory submissions), drug discovery (patent applications), drug development and other types of R&D studies – pharm/tox, bio distribution and imaging studies. Altogen Labs was established in 2009 in Austin,… Continue Reading

Altogen Labs offers in vivo imaging services for drug development and biodistribution studies: Orthotopic glioma xenograft model

Altogen Labs provides in vivo imaging services for drug development and biodistribution studies: Example of U87 orthotopic glioma xenograft animal model study  by Altogen Labs, 11200 Manchaca Rd, Suite 203 Austin TX 78748 USA  Introduction In vivo imaging has emerged as a critical tool in visualization in preclinical research studies related to the development of new… Continue Reading

Biology CRO Contract Research Services to Accelerate Preclinical and Oncology Research Studies

Altogen Labs, a CRO laboratory located in Austin, Texas (USA), provides preclinical pharmacology and oncology contract research services for pharmaceutical, biotechnology, and academic research institutions worldwide. Company scientists bring years of experience and expertise in life science and drug discovery research services. Altogen Labs offers GLP-compliant research and development services that include preclinical trials to… Continue Reading

Altogen Labs Offers Pre-Clinical CRO Services to Accelerate Pre-Clinical Research Needs

Altogen Labs, a biotechnology company focused on providing biotechnology research services for pharmaceutical, biotechnology, and academic institutions worldwide, announced pre-clinical contract research services enabling companies to accelerate pre-clinical research needs. Pre-clinical trials assess the toxicity and pharmacological activity of investigative new drugs (INDs) to assess a compound’s therapeutic potential and safety for human use. A… Continue Reading

Comparison of Commercial Transfection Reagents: Cell line optimized transfection kits for cancer research studies

Comparison of Commercial Transfection Reagents: Cell line optimized transfection kits for in vitro cancer research. by Altogen Labs, 11200 Manchaca Road, Suite 203 Austin TX 78748 USA Tel. (512) 433-6177 E-mail: info@altogenlabs.com  Website: www.altogenlabs.com Introduction The process of in vitro transfection involves introduction of genetic material into cells and it is generally used for mammalian… Continue Reading

Altogen Labs Launches In Vivo siRNA Liposome Encapsulation Services

Altogen Labs has announced the release of a new contract research services (CRO) product: small interfering RNA (siRNA) liposome encapsulation, a technique used in biology laboratories to enable in vivo delivery of siRNA. Liposome encapsulation platform uses latest microfluidizer (Microfluidics) technology and is unique in its ability to achieve liposomal protection of functional siRNA molecules, provide… Continue Reading