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Medical Discovery and Innovation: Altogen Labs Preclinical CRO Services

Altogen Labs (altogenlabs.com), an Austin, TX based contract research organization (CRO) offers preclinical laboratory services to pharmaceutical, biotechnology, and academic researchers worldwide to support and accelerate medical discovery and research studies. Our Good Laboratory Practice (GLP)-compliant laboratory offers services for drug toxicology, drug efficacy, drug discovery and new medicine development, specifically supporting preclinical investigation with in vitro and in vivo services including anti-cancer compound screening, IC50 assays, stable-cell line engineering, over 80 validated xenograft models, gene function and expression analysis, in-vivo RNAi and tissue-targeted siRNA delivery, transient and stable transfections of cell lines, engineering of RNAi knockdown celllines, microfluidics-based liposome encapsulation, and cell-based assay development.

Outsourcing preclinical research projects is an effective and efficient means of ensuring that limited time resources are invested
proportionately into the highest priority facets of the project. It is our goal to partner with our clients to deliver the most efficient and reliable delivery of products and services to ensure that any research project is progressing at the fastest rate possible, and that all preclinical experiments and data have been rigorously studied and analyzed prior to transitioning into clinical research to ensure maximum probability of project success. Altogen Labs is committed to satisfying our clients’ timely needs while concurrently delivering results of the highest quality and integrity.

Altogen Labs offers in vitro toxicology studies of INDs to characterize the drug candidate’s effects on biological functions and metabolism. Cancer cell lines are used as in vitro models for dose-response studies. Our laboratory houses a large catalog of cancer cell lines to be screened for IC50 values of candidate drugs. Our research laboratory provides IC50 studies by screening candidate drugs against our extensive library of cell lines or against client provided custom cell lines. For in vivo research, Altogen Labs offers xenografting – the method of transplanting human tumor tissue into immunocompromised mice to create a more biologically
accurate model to investigate an IND’s effect on tumor activity. Altogen Labs offers consultation to our clients on xenograft model selection. Xenograft studies are GLP compliant and animal handling at our facility is IACUC-regulated.

Our team of scientists is equipped to perform research studies utilizing more than 80 xenograft models including models for brain carcinoma, pancreatic and breast cancer, epidermoid and nasopharyngeal carcinoma, and xenograft studies for melanoma, colon, breast, lung, and prostate cancers. Additionally, over 20 patient PDX xenograft models are also available. Clients employing xenograft studies are provided with detailed experimental procedures, health reports, and experimental data. These
studies can be further expanded to include tissue collection, histology, RNA isolation, and gene expression analysis.

Read full article (Global Health & Pharma Magazine, April 2017)

Altogen Labs offers xenograft services for drug development of anti-cancer therapeutics

Altogen Labs provides xenograft services for drug development studies of anti-cancer therapeutics by Altogen Labs, Preclinical CRO, 11200 Manchaca Rd, Suite 203 Austin TX 78744 USA (512-433-6177) Contact e-mail: info@altogenlabs.com Introduction Xenograft studies fuels the development of new therapeutics efficiently and effectively and remains the gold standard for preclinical oncology research [1]. Xenograft studies, over… Continue Reading

Preclinical Contract Research Studies by Global Health & Pharma

Altogen Labs is a good laboratory practice (GLP) compliant laboratory that provides biotechnology research services for pharmaceutical, biotechnology, and academic institutions worldwide. Altogen Labs services include safety in vivo toxicology studies (for IND applications), efficacy studies (for regulatory submissions), drug discovery (patent applications), drug development and other types of R&D studies – pharm/tox, bio distribution and imaging studies. Altogen Labs was established in 2009 in Austin,… Continue Reading

Altogen Labs offers in vivo imaging services for drug development and biodistribution studies: Orthotopic glioma xenograft model

Altogen Labs provides in vivo imaging services for drug development and biodistribution studies: Example of U87 orthotopic glioma xenograft animal model study  by Altogen Labs, 11200 Manchaca Rd, Suite 203 Austin TX 78748 USA  Introduction In vivo imaging has emerged as a critical tool in visualization in preclinical research studies related to the development of new… Continue Reading

Biology CRO Contract Research Services to Accelerate Preclinical and Oncology Research Studies

Altogen Labs, a CRO laboratory located in Austin, Texas (USA), provides preclinical pharmacology and oncology contract research services for pharmaceutical, biotechnology, and academic research institutions worldwide. Company scientists bring years of experience and expertise in life science and drug discovery research services. Altogen Labs offers GLP-compliant research and development services that include preclinical trials to… Continue Reading

Altogen Labs Offers Pre-Clinical CRO Services to Accelerate Pre-Clinical Research Needs

Altogen Labs, a biotechnology company focused on providing biotechnology research services for pharmaceutical, biotechnology, and academic institutions worldwide, announced pre-clinical contract research services enabling companies to accelerate pre-clinical research needs. Pre-clinical trials assess the toxicity and pharmacological activity of investigative new drugs (INDs) to assess a compound’s therapeutic potential and safety for human use. A… Continue Reading

Comparison of Commercial Transfection Reagents: Cell line optimized transfection kits for cancer research studies

Comparison of Commercial Transfection Reagents: Cell line optimized transfection kits for in vitro cancer research. by Altogen Labs, 11200 Manchaca Road, Suite 203 Austin TX 78748 USA Tel. (512) 433-6177 E-mail: info@altogenlabs.com  Website: www.altogenlabs.com Introduction The process of in vitro transfection involves introduction of genetic material into cells and it is generally used for mammalian… Continue Reading

Altogen Labs Launches In Vivo siRNA Liposome Encapsulation Services

Altogen Labs has announced the release of a new contract research services (CRO) product: small interfering RNA (siRNA) liposome encapsulation, a technique used in biology laboratories to enable in vivo delivery of siRNA. Liposome encapsulation platform uses latest microfluidizer (Microfluidics) technology and is unique in its ability to achieve liposomal protection of functional siRNA molecules, provide… Continue Reading

PEG-Liposome siRNA In Vivo Transfection Kit From Altogen

Altogen announced the release of its second generation of in vivo RNAi transfection reagent in the company’s popular in vivo delivery product line: PEG-Liposome siRNA In Vivo Transfection Kit. This reagent is compatible for in vivo transfection of other negatively charged molecules – RNA, DNA, and small proteins. The company also offers custom encapsulation of target molecules Read Continue Reading