Xenograft Animal Service
In Vivo siRNA Delivery
Generation of Stable Cell Line
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Altogen Labs provides over 50 xenograft cancer animal models (biodistribution, PK/PD, imaging studies). We offer assistance in choosing the best model suitable for clients experimental goals. Animal handling and maintenance at our facility is IACUC-regulated and GLP-compliant. We provide detailed experiment procedures, health reports and experimental data.

Xenograft Animal Service
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Altogen Labs provides A-to-Z RNAi in vivo delivery services: custom si/miRNA liposome encapsulation, chemical modification, in vitro validation, in vivo tissue-targeted delivery. Assays include: oligonucleotide accumulation (TaqMan), target mRNA (RT-PCR) and protein expression levels (WB and ELISA).

In Vivo siRNA Delivery
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Stable cell lines over-expressing a protein of interest, or RNAi construct targeting a gene of interest, are powerful research tools for the production of recombinant antibodies, drug screening, and gene function studies. Altogen Labs provides service of stable cell line development completed in 28 days.

Generation of Stable Cell Line
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Preclinical Services: Xenograft studies, Safety Pharm/Tox Assays

Altogen Labs is a Good Laboratory Practice (GLP)-compliant CRO laboratory that provides biotechnology research services for pharmaceutical, biotechnology, and academic institutions worldwide. Our services include safety in vivo toxicology studies (for IND applications), efficacy studies (for regulatory submissions), drug discovery (patent applications), drug development and other types of R&D studies – pharm/tox safety, biodistribution and imaging studies. We provide a variety of biology CRO laboratory in vivo services, including 80 CDX and over 30 PDX xenograft models, and 10 syngeneic murine models. All xenograft models are validated in-house. Our in vitro services includes IC50/LD50 safety studies, assays, development of stable cell lines, gene function and gene expression analysis (measurement of mRNA levels by RT-PCR and protein expression levels by automated Western Blot system WES), RNAi and tissue-targeted siRNA delivery services, transient and stable transfections, compound liposome encapsulation, and more.

Preclinical research studies often require a sequence of experiments utilizing various scientific methods to demonstrate novel compound efficacy, safety, and mechanism of action. Altogen scientists have years of experience and expertise that includes all types of preclinical contract research studies (biology CRO), cell and molecular biology research and development services, pharmacology and toxicology safety studies that are required for IND. We provide a wide range of GLP laboratory services to meet clients’ unique needs, including stable cell line development in 28 days, A-to-Z complete RNAi services (from oligonucleotide design and synthesis to tissue-targeted delivery), anti-cancer compound testing, liposome encapsulation (proteins, plasmid DNA, si/shRNA, mRNA, and small molecules), cryopreservation and cell banking services. Technical support and QA/QC teams ensure and support the company’s high-quality products and services. We support clients from study design phase through patent or regulatory submissions (100% of IP belongs to the client).

Altogen Labs offers instant quotes (info@altogenlabs.com, or call us at 512-433-6177), comprehensive service packages, and highly competitive prices. We are happy to discuss your experimental details to help generate accurate price quotes and timeline estimates.