Preclinical Studies: Xenograft (efficacy) and Pharm/Tox (safety)
Our preclinical services include safety in vivo toxicology studies (for IND applications), efficacy studies (for regulatory submissions), drug discovery (patent applications), drug development, and other types of R&D studies including pharm/tox safety, biodistribution, and imaging studies. Altogen Labs is a Good Laboratory Practice (GLP)-compliant CRO laboratory that provides biotechnology research services for pharmaceutical, biotechnology, and academic institutions worldwide. We provide a variety of biology CRO laboratory in vivo services, including 92 CDX, 34 PDX xenograft models, and 12 syngeneic murine models. All xenograft models are validated in-house. Our in vitro services include IC50/LD50 safety studies, development of stable cell lines, gene function and gene expression analysis (mRNA levels by RT-PCR and protein expression levels by automated Western Blot system WES), RNAi and tissue-targeted siRNA delivery services, transient and stable transfections, compound liposome encapsulation, and more.
Nonclinical research studies often require a sequence of experiments utilizing various scientific methods to demonstrate novel compound efficacy, safety, and mechanism of action. Altogen scientists have years of experience and expertise that includes all types of preclinical contract research studies (biology CRO), cell and molecular biology research and development services, pharmacology, and toxicology safety studies that are required for IND.