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AUSTIN, Texas – August 30, 2009 – Altogen Labs today detailed its genome-wide siRNA and microRNA high-throughput screening services, supporting sponsors and academic groups conducting unbiased target discovery and pathway analysis.
Genome-scale RNAi screening is among the most demanding work a contract laboratory can undertake. It requires consistent transfection efficiency across thousands of wells, tight assay windows, rigorous plate-to-plate normalization, and analytical capability equal to the data volume generated. A screen executed inconsistently produces a hit list dominated by noise, and the cost of chasing false positives dwarfs the cost of the screen itself.
Altogen Labs brings a specific advantage to this work: the company’s affiliated technology base includes cell type-specific transfection reagents optimized across more than 100 cell lines, meaning screens can be run in the biologically appropriate cell type rather than in whichever line transfects most easily.
The service portfolio spans genome-wide screens, RNAi screen pathway analysis for siRNA and microRNA, cell-based library screening, and quantitation of siRNA-induced knockdown by qRT-PCR and Western blot. Hits identified in a screen can be validated within the same laboratory through stable RNAi cell line generation, tetracycline-inducible knockdown systems, and finally in vivo confirmation in the company’s validated tumor models. That continuity, screen to validation to in vivo, is what converts a hit list into a therapeutic target.
About Altogen Labs Altogen Labs is a professional, experienced, and highly reputable GLP-compliant contract research organization providing preclinical research and biology CRO services to pharmaceutical, biotechnology, and academic institutions worldwide, with a large collection of validated xenograft models and extensive experience in efficacy xenograft and safety toxicology studies.
Contact Information: Altogen Labs | 11200 Menchaca Rd, Bldg 2, Suite 203 | Austin, TX 78748 USA Tel: 512-433-6177 | Email: info@altogenlabs.com | Web: altogenlabs.com