Altogen Labs CRO Services:
- PRE-CLINICAL RESEARCH SERVICES
- Pharmacology and Toxicology Testing: IC50 for Tumor Cell Lines
- Xenograft Animal Service: Immunocompromised NOD/SCID Mice
- Therapeutic RNAi Development: Targeted siRNA, qPCR Assays
- Liposome Encapsulation Services: siRNA, miRNA, DNA, Proteins
- ELISA and Cell-Based Assay Development (Cell Cycle, Viability)
- Apoptosis Assay: Caspase-3 and Caspase-7 Cell Line Screen
- RNAi Consulting: Technology Development and Evaluation
- GENERATION OF STABLE CELL LINES
- CELL BANKING SERVICES
- RNA INTERFERENCE (RNAi) SERVICES
- In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi)
- siRNA Transfection and RNAi Cell-based Library Screening
- Generation of Tet-inducible RNAi Gene Knockdown Cell Lines
- RNAi Screen Pathway Analysis: siRNA and microRNA
- RNAi Manufacturing and CRO Services
- PCR Cloning: DNA Vector Construction (shRNA)
- Quantitation sh/siRNA-induced Knockdown by qRT-PCR and WB
- Genome-wide siRNA and microRNA High-throughput Screens
- Stable RNAi Cell Line Generation: Stable Gene Knockdown
- siRNA Liposome Encapsulation Service
- Transient (siRNA) and Stable (shRNA) Transfection Services
- BIOLOGY LABORATORY CRO SERVICES
- BIOREMEDIATION SERVICES
- MICROORGANISM ID SERVICE
BIOLOGY LABORATORY CRO SERVICES
Altogen Labs extensive biotechnology and pharmacology BIOLOGY LABORATORY CRO SERVICES include the following:
- In Vivo Toxicology Service (Mouse, Rat)
- Teratoma Formation and Analysis Service
- Stimulation of Adipogenesis (Gly)
- Cell Culture Decontamination Service
Altogen Labs provides a variety of biology laboratory CRO research services, including in vivo toxicology studies and preclinical trials to measure the toxicity and pharmacological activity of investigative new drugs (INDs) to assess a compound’s therapeutic potential and safety for human use. All services are GLP compliant and in vivo services are regulated by IACUC.
In vivo toxicology analysis services include evaluation of drug toxicity in vitro (cell culture) and in vivo (rodents). In vitro studies are designed to measure the mechanisms of chemical-induced and drug-induced toxicity on target cells without the living biological systems’ metabolic and immune system interference. After completing in vitro studies, the experimental compound can then be tested in a living system (in vivo) referred to as a biological model system. In a such model system, the compound can be administered through a variety of methods (intravenous, intraperitoneal, oral, intratumoral, intramuscular, intratracheal, subcutaneous, etc) as described and defined by the IACUC protocol and with a variety of dosage concentrations (to establish dose-response phenotype).
At Altogen Labs in vivo toxicology services are designed to measure acute, chronic and subchronic toxicology of INDs based on the length of time that a given substance is exposed to the subject. Acute toxicity exposure is used for examining the short-term side effects of a single large dosage of a compound. Subchronic and chronic toxicology are used to examine the long-term toxicological effects of experimental compound. The overall goal of in vivo toxicology studies is to provide information to anticipate and optimize the efficacy and potential toxicological effects of experimental compound.
We also offer complete A-to-Z RNAi gene silencing services: gene targeting, siRNA synthesis, chemical modification, functional in vitro validation, siRNA encapsulation, in vivo siRNA protection, and tissue targeted delivery.
After discussing the details of your project, we can provide an immediate price quote (contact e-mail: info@altogenlabs.com or call Altogen Labs technical support: 512-433-6177). Please note that experimental details will help us provide an accurate quote and timeline estimate.