Personalized Oncology Services: Patient-Derived Chemosensitivity Xenografts
Development of standard chemotherapies often based on clinical trials data. While various anticancer compounds can show positive effects in certain patients, it is often a guess which chemotherapy treatment will work the best. A personalized oncology xenograft service provides such opportunity by testing chemotherapy effect outside of the patient. This is performed by xenotransplantation of patient’s tumor piece (or biopsy) in an immunocompromised mouse, letting it grow, followed by testing chemotherapy effectiveness on inhibiting the tumor growth. Results from personalized xenograft testing can show which chemotherapies (or combination of chemotherapies) can fight best against patients specific cancer.
Personalized Oncology Xenograft Services provided by Altogen Labs:
There are several steps in the process of obtaining a patient-derived xenograft:
- A tissue sample from a patient’s tumor must be obtained (piece of tumor, or biopsy).
- The tumor tissue piece (once extracted) must be transplanted in immunocompromized mice.
- The tumor sample is grown in vivo for 6-8 weeks.
- The tumor is dissected into several parts, and re-implanted in other set of immunocompromized mice for follow up testing.
- Chemosensitivity drug test is performed (chemotherapy set can be chosen by the patient and their doctor).
- The results (list of most effective chemotherapies, and/or their combination) are reported to the patient and their oncologist.
Read more about the Cost, Tumor Extraction Procedure, and Patient Responsibilities: 14 Weeks PDX and Chemotherapy Testing